effects of vitamins c and e on serum resistin, hs-crp, lipid profile and insulin levels in patients with type 2 diabetes

abstract          background and objective: vitamins c and e are  the two main antioxidants involved in prevention of type 2 diabetes, by reducing oxidative stress. the aim of this study was to evaluate the effects of vitamins c and e supplementation independently, on serum levels of insulin, high sensitivity c-reactive protein (hs-crp) and resistin in people with type 2 diabetes.         methods: in this study, 38 patients with type 2 diabetes (17 men and 21 women) received 1,000 mg/day vitamin c, and 40 patients with type 2 diabetes (21 men and 19 women) received 400 iu/day vitamin e orally. fasting blood glucose and lipid profile were measured using enzymatic method. hs-crp was measured by immunoturbidimetric method, and serum insulin and resistin levels were measured by elisa.          results: total cholesterol, triglycerides, hs-crp, insulin and resistin significantly were reduced after vitamin c supplementation (p<0.001). moreover, the level of total cholesterol (p =0.018), low-density lipoprotein, triglycerides and hs-crp significantly changed after vitamin e supplementation (p=0.001).           conclusion: the daily intake of 1,000 mg of vitamin c and 400 iu of vitamin e may be useful in reducing diabetic complications by decreasing serum levels of hs-crp and lipid profile in people with type 2 diabetes.